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Ondansetron instructions for use.
Dosage forms
coated tablets 4mg
Producers
Ocaso Pharma Ltd. (India)
FarmGruppa
Antiemetics
International nonproprietary name
Ondansetron
The order of release
Prescription
Synonyms
Vero-Ondansetron, Zofran, Latran, Ondansetron-Altfarm, Ondansetron, Lance, Ondansetron, Ferein, ondansetron hydrochloride dihydrate, Osetron, Setronon, Emeset, Emetron
Composition
Active substance - ondansetron.
Pharmacological action
Antiemetic. The competitive type of highly selective blocking central (chemoreceptors trigger zone, vomiting center) and peripheral serotonin 5-HT3-receptor. Suppresses the gag reflex, removes and prevents vomiting mediated release of serotonin in the application of cytostatic protivoblastomnyh funds (cisplatin, etc.), radiotherapy in the postoperative period. When multiple doses slows peristalsis and passage of the contents of the intestines. After iv injection 0.15 mg / kg the maximum concentration is for age groups 19-40, 61-74, 75 years or more 102, 106 and 170 ng / ml, elimination half-life - 3,5, 4,7 and 5 , 5:00. The maximum concentration in the i / m administration recorded after 10 minutes. In the gastrointestinal tract is well absorbed. The maximum concentration at intake is achieved through a 1.7 hour half-life - 3 hours. Bound to plasma proteins at 70-76% (respectively, 10-500 ng / ml in vitro), partially penetrates into erythrocytes. In women, the rate and duration of suction from the gastrointestinal tract, the absolute bioavailability and plasma parameters above, and the clearance rate and distribution are lower than men's.
Indications for use Ondansetron
Nausea and vomiting (prophylaxis) with cytotoxic chemotherapy (initial and repeat courses, including the use of high-dose cisplatin), radiotherapy (irradiation of the entire body surface, a partial high-single or daily exposure of the abdominal region), in the postoperative period.
Contra Ondansetron
Increased sensitivity, insufficiency of liver function, surgery on the abdomen, pregnancy (especially during the first 3 months), lactation, children's age: up to 2 years in the case of anesthesia, and 4 years - during chemotherapy, all age group - with radiation therapy and for the appointment suppositories.
Side effect
Constipation, diarrhea, dry mouth, hiccups, transient increase of aspartate and alanine aminotransferase, hepatic failure (can be fatal, especially against the hepatotoxic protivoblastomnoy therapy and antibiotics), headache, dizziness, visual disturbances (blurred, accommodation disorders), a feeling of warmth and flare, CNS depression, paresthesia, weakness, seizures, extrapyramidal symptoms, hypokalemia, tachycardia or bradycardia, hypotension, fainting, chest pain (angina type), violations of the ECG, including the blockade of the II degree, fever, allergic reaction: hives , bronchospasm, angioedema, anaphylaxis, pain, redness and burning at the injection site, a burning sensation in the anus and rectum (suppositories).
Interaction
Compatible with the infusion solutions of sodium and potassium chloride, dextrose, mannitol, Ringer, cisplatin, fluorouracil, carboplatin, etoposide, ceftazidime, cyclophosphamide, doxorubicin, dexamethasone.
Overdose
No information available.
Cautions
Not recommended that you enter in the same syringe with other drugs. Injectable forms of divorce only recommended solutions.
Storage conditions
List B. In sheltered from the light, at a temperature not exceeding 25 ° C.
